From Hypercholesterolemic Patients Simvastatin Reduces the Expression of Adhesion Molecules in Circulating Monocytes
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چکیده
Maca, Hans-Georg Kress, Peter Valent, Bernd R. Binder, Erich Minar and Mehrdad Abdolreza Rezaie-Majd, Gerald W. Prager, Robert A. Bucek, Gerit H. Schernthaner, Thomas From Hypercholesterolemic Patients Simvastatin Reduces the Expression of Adhesion Molecules in Circulating Monocytes Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2003 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000059384.34874.F
منابع مشابه
Simvastatin reduces the expression of adhesion molecules in circulating monocytes from hypercholesterolemic patients.
OBJECTIVE The intercellular adhesion molecule-1 (ICAM-1/CD54) and its ligand, CD11a/CD18, mediate endothelial adhesion of leukocytes and their consecutive transmigration. Anti-inflammatory effects of statins are considered to be exerted in part through inhibition of leukocyte-endothelial interactions. We investigated the in vivo effects of simvastatin treatment in hypercholesterolemic patients ...
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متن کاملSimvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients.
OBJECTIVE A number of studies have shown that statins decrease morbidity and mortality in patients with cardiovascular diseases. The anti-inflammatory effects of statins have recently been implicated in the clinical benefit that can be obtained in the treatment of atherosclerosis. Little is known about the mechanisms by which statins counteract inflammation. METHODS AND RESULTS In this study,...
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